PC Technology is a proprietary platform of innovative materials that can improve the biocompatibility and performance of medical devices through reduced:
In addition, PC coatings offer versatile solutions for controlled drug delivery.
- protein deposition and activation
- blood activation and thrombus formation
- bacterial adhesion and biofilm deposition
- inflammatory response
- capsule formation
All PC products are stable, non-toxic and bio-inert materials with simple application and processing methods, which makes them easy to integrate into existing manufacturing processes.
All PC products have either FDA material master files or Vertellus Technical Files that have been assembled using FDA guidelines. Customers are provided with an FDA letter of access to our master files or use our own Technical Files in the preparation of their regulatory submissions. This increases speed to market and in the case of US submissions, the 510(k) route can often be taken (depending upon device classification).
Typical PC coatings and bulk materials are shown in the table below, which also outlines their individual characteristics and typical medical device applications.
|PC1036||'Standard' cross-linked PC coating||High durability drug delivery matrix||Drug-eluting stents, urology, otology etc|
|| 'Standard' non cross-linked PC coating
|| Stable through hydrophobic surface interactions || Guide wires, CPB systems, blood processing devices |
|PC2118|| Cross-linked PC coating with very high level of PC || Coating yields self-priming surfaces || Blood filtration and processing |
|PC1062|| Cross-linked PC coating with low level of positive charge || Binds heparin to form anti-thrombogenic coating || Blood filtration and processing |
|PC2028|| Cross-linked PC coating with high level of positive charge || Matrix for delivery of high Mw drugs || Drug-eluting stents |
|PC1071||Vinyl functional in-mould PC coating||Applied to curable materials e.g. silicones|| Otology |
|PC1015|| Cross-linked PC hydrogel || Bulk material for moulding || Contact lens |
|PC2083|| Flexible PC hydrogel with high refractive index || Bulk material for moulding || Contact lens |
Biocompatible PC gel systems are also under development for tissue bulking applications to compensate for loss of mass, shape or elasticity.
Vertellus is constantly adding to this list and is also developing materials for applications outside the healthcare area where the unique hydration and anti-fouling features of PC can bring benefits.